Influence of physical and chemical treatments upon the microsomal enzymes of testes related to androgen biosynthesis.
نویسندگان
چکیده
Testicular microsomal fraction (10,000•`105,000 •~ g precipitates) of adult rats which was responsible for enzymic transformation of pregnenolone into testosterone was inactivated by phospholipases C and D, but not by phospholipase A . After the 10 kilocycles/sec. sonication for 60 mins., most of the microsomal enzyme activities were still found in the 105,000 •~ g precipitates. The specific activities of the enzymes in the
منابع مشابه
P-91: Androgen Associated Gene Polymorphism(s) in Women with Polycystic Ovary Syndrome from South Indian Population
Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder affecting 4-12% of reproductive women worldwide; characterized by chronic anovulation, clinical and/or biochemical hyperandrogenism, and polycystic ovaries on ultrasound scan. Ovarian androgen overproduction is the key pathophysiologic feature of PCOS. A number of genes encoding major enzymes of the androgen meta...
متن کاملInhibitors of steroidal cytochrome p450 enzymes as targets for drug development.
Cytochrome P450's are enzymes which catalyze a large number of biological reactions, for example hydroxylation, N-, O-, S- dealkylation, epoxidation or desamination. Their substrates include fatty acids, steroids or prostaglandins. In addition, a high number of various xenobiotics are metabolized by these enzymes. The enzyme 17alpha-hydroxylase-C17,20-lyase (P450(17), CYP 17, androgen synthase)...
متن کاملModulation of Leydig cell androgen biosynthesis and cytochrome P-450 levels during estrogen treatment and human chorionic gonadotropin-induced desensitization.
The mechanisms responsible for gonadotropin-induced testicular desensitization were analyzed by direct assay of androgen biosynthetic enzymes and cytochrome P-450 in microsomes and cytosol from testes of adult male rats. Animals were treated with single subcutaneous doses of human chorionic gonadotropin (hCG) (2 and 10 pg) to induce a post-stimulation decrease in testosterone production, previo...
متن کاملInfluence of Copper and Zinc on Growth, Metal Accumulation and Chemical Composition of Essential Oils in Sweet Basil (Ocimum basilicum L.)
Background: Biosynthesis and metabolism of phytochemicals in medicinal and aromatic plants are vigorously affected by different abiotic elicitors including chemicals. Objective: This experiment was designed to investigate the effects of three levels of copper sulfate (Cu: 0, 5, 25 mg kg-1) and zinc sulfate (Zn: 0, 10, 50 mg kg-1) and their combinations on yield, chemical compositions of esse...
متن کاملTranscriptional Response of Structural and Regulatory Genes Involved in Isoprene Biosynthesis and its Relation to Essential Oil Biosynthesis in Response to Salicylic Acid and Abscisic Acid in Mentha piperita L.
Background: In peppermint, precursors for the biosynthesis of monoterpenes are provided by plastidial methyl-erythritol-phosphate (MEP) pathways. Objective: In order to increase our understanding of terpene metabolism in M. piperita, the effect of salicylic acid (SA) and abscisic acid (ABA) in the modulation of expression pattern of genes involved in essential oil biosynthesis and secretion wa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Endocrinologia japonica
دوره 16 1 شماره
صفحات -
تاریخ انتشار 1969